超几何累积分布检验overlap

 复现文章中检验基因的overlap 使用R中的phyper函数实现: -log10(phyper(58, 555, 19738-555,660, lower

 复现文章中检验基因的overlap

 使用R中的phyper函数实现:

-log10(phyper(58, 555, 19738-555,660, lower.tail = F))
#[1] 14.44417

扩展: 

phyper(x, m, N-m, n, lower.tail = TRUE, log.p = FALSE)

文章

[1] Moncada R ,  Barkley D ,  Wagner F , et al. Integrating microarray-based spatial transcriptomics and single-cell RNA-seq reveals tissue architecture in pancreatic ductal adenocarcinomas[J]. Nature Biotechnology.